Blar i SINTEF Open på forfatter "van Wamel, Annemieke"

Viser treff 1-5 av 5

    • Multi-modal characterization of vasculature and nanoparticle accumulation in five tumor xenograft models 

      Sulheim, Einar; Kim, Jana; van Wamel, Annemieke; Kim, Eugene; Snipstad, Sofie; Vidic, Igor; Grimstad, Ingeborg; Widerøe, Marius; Torp, Sverre Helge; Lundgren, Steinar; Waxman, David J.; Davies, Catharina de Lange (Peer reviewed; Journal article, 2018)
      Preclinical research has demonstrated that nanoparticles and macromolecules can accumulate in solid tumors due to the enhanced permeability and retention effect. However, drug loaded nanoparticles often fail to show increased ...

    • The Effect of Sonication on Extravasation and Distribution of Nanoparticles and Dextrans in Tumor Tissue Imaged by Multiphoton Microscopy 

      Yemane, Petros Tesfamichael; Åslund, Andreas; Sæterbø, Kristin Grendstad; Bjørkøy, Astrid; Snipstad, Sofie; van Wamel, Annemieke; Berg, Sigrid; Mørch, Ýrr Asbjørg; Hansen, Rune; Angelsen, Bjørn Atle Johan; Davies, Catharina de Lange (Journal article; Peer reviewed, 2018)
      Ultrasound (US)and systemic administration of microbubbles (MBs)have been shown to improve the delivery of drugs and nanoparticles (NPs)to tumor tissue. A better understanding of the mechanisms is crucial for effective ...

    • Ultrafast Microscopy Imaging of Acoustic Cluster Therapy Bubbles: Activation and Oscillation 

      van Wamel, Annemieke; Mühlenpfordt, Melina; Hansen, Rune; Healey, Andrew; Villanueva, Flordeliza S.; Kotopoulis, Spiros; Davies, Catharina de Lange; Chen, Xucai (Peer reviewed; Journal article, 2022)
      Acoustic Cluster Therapy (ACT®) is a platform for improving drug delivery and has had promising pre-clinical results. A clinical trial is ongoing. ACT® is based on microclusters of microbubbles–microdroplets that, when ...

    • Ultrasound Improves the Delivery and Therapeutic Effect of Nanoparticle-Stabilized Microbubbles in Breast Cancer Xenografts 

      Snipstad, Sofie; Berg, Sigrid; Mørch, Ýrr Asbjørg; Bjørkøy, Astrid; Sulheim, Einar; Hansen, Rune; Grimstad, Ingeborg; van Wamel, Annemieke; Maaland, Astri Fjelde; Torp, Sverre Helge; Davies, Ruth Catharina de Lange (Peer reviewed; Journal article, 2017)
      Compared with conventional chemotherapy, encapsulation of drugs in nanoparticles can improve efficacy and reduce toxicity. However, delivery of nanoparticles is often insufficient and heterogeneous because of various ...

    • Ultrasound-mediated delivery enhances therapeutic efficacy of MMP sensitive liposomes 

      Olsman, Marieke; Sereti, Viktoria; Andreassen, Kristine; Snipstad, Sofie; van Wamel, Annemieke; Eliasen, Rasmus; Berg, Sigrid; Urquhart, Andrew J.; Andersen, Thomas L.; Davies, Catharina de Lange (Peer reviewed; Journal article, 2020)
      To improve therapeutic efficacy of nanocarrier drug delivery systems, it is essential to improve their uptake and penetration in tumour tissue, enhance cellular uptake and ensure efficient drug release at the tumour site. ...